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Description

Blood-brain barrier alterations in the cerebral cortex in experimental autoimmune encephalomyelitis

it primarily functions as an upstream regulatory factor to modulate ferroptosis, whereas ferroptosis is a well-defined death execution pathway culminating in lipid peroxidation

For example, they lower free iron levels by inhibiting the expression of genes encoding transferrin receptor protein 1 (TFRC) and ferritin while promoting ferroportin production