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Moving forward, understanding proteostasis at a systems level, as an interactome rather than a pathway, will be essential for decoding disease mechanisms and designing truly effective therapeutic interventions

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Introduction Autism spectrum disorder (ASD) is a pervasive neurodevelopmental disorder characterized by impaired communication and social interaction, as well as repetitive/stereotyped behaviors ( Admittedly, numerous publications have indicated that the pathogenesis of ASD was affected by immune dysregulation/inflammation, oxidative stress, and mitochondrial dysfunction ( Strikingly, existing evidence has indicated that Nrf2 plays an important role in immune dysregulation/inflammation, oxidative stress, and mitochondrial dysfunction