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Berberine has been shown to inhibit cancer cell proliferation by upregulating LDL receptors and inhibiting lipid synthesis pathways, such as fatty acid synthase, through activation of the AMPK pathway, which reduces cholesterol and lipid accumulation in tumor cells (82)

Iron storage in ferritin is largely determined by the level of ferritin protein, which is tightly regulated according to cellular iron levels (reviewed in )

Proc Natl Acad Sci 100:1467214677 Singla-Pareek SL, Yadav SK, Pareek A, Reddy MK, Sopory SK (2006) Transgenic tobacco overexpressing glyoxalase pathway enzymes grow and set viable seeds in zinc-spiked soils