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Further corroborating our results, GATA6 was among the top BMP9/10 upregulated genes 37

In contrast to large scale GWAS which have not established an association between CLOCK genes and bipolar disorder, smaller linkage studies, while lacking adequate replication, have noted an association between several circadian genes, including TIMELESS, ARNTL1, PER3, NR1D1, CLOCK, and GSK-3 beta, and the bipolar illness (181, 182, 186)