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The authors declare that they do not have a conflict of interest

PDRN (polydeoxyribonucleotide) is a bioactive compound derived from salmon DNA that acts as an A2A adenosine receptor agonist

These findings are consistent with DLVO theory, where increased surface charge improves colloidal stability [42, 44], whereas higher lipid content reduces electrostatic stabilization and promotes vesicle growth [33]