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This includes the production of numerous pro-inflammatory cytokines such as TNF- and pro-IL-1 and chemokines which induce signaling cascades that promote the differentiation of FLS into myofibroblasts via auto- and paracrine signaling (169)

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The disease further entails gut DCs overactivation, resulting in increased levels of IL-6in the serum and intestine of IBD patients

Complexities and Diversity of Human Anti-Neu5Gc Antibodies Although their target was then unknown, anti-Neu5Gc antibodies were actually described almost a century ago, when Hanganutziu and Deicher observed that serum from patients that received animal antisera during therapy, could agglutinate animal red blood cells (Hanganutziu, 1924