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As in T2D, APD-induced increases in circulating insulin are hypothesized to desensitize insulin-sensitive peripheral targets (e.g., liver, skeletal muscle, adipose tissue) over time, resulting in insulin resistance and weight gain 3,4,15

Nephrin and podocin functions are highly conserved between the zebrafish pronephros and mammalian metanephros

The activity of luciferase was no longer reduced (Figure 5G)

Elevated levels of H 2 O 2 also are associated with the oxidation of other amino acids, leading to the formation of methionine sulfoxide and a variety of carbonyls