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The preclinical data is generally consistent and encouraging

Verhoef P, Stampfer M, Buring J, Gaziano J, Allen R, Stabler S, Reynolds R, Kok F, Hennekens C, Willett W

In fact, CD38 knockout mice exhibit significant increases in both extra- and intracellular NAD + levels ( Because of its ability to use NAD + as a substrate, CD38 has been hypothesized to act as a metabolic sensor, limiting the duration of NAD + half-life and signaling in the extracellular compartment