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Primary sclerosing cholangitis: clinical presentation, natural history and prognostic variables: an Italian multicentre study

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Except for three studies that had cross-over design, (Reference Nogueira, Nogueira Neto, Klein and Sanjuliani46,Reference Sone, Kuriyama and Nakaya61,Reference Fukino, Ikeda, Maruyama, Aoki, Okubo and Iso65) the majority of studies took advantage of a parallel design