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Hagiwara et al., 2012) and may contribute to lifespan extension in rodents ( Thus, proper modulation of glucose and mTORC1-2 pathways suggests that it may enhance the robustness of circadian rhythms, as happens in the naked mole-rat and slow down the aging process by improving metabolic health and reducing cellular damage

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Here, we selected the culture intervals of days 46 as this transition period captures the critical moment where cells actively reconfigure their metabolic networks after peak growth divergence during days 24