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Type I IFNs (IFNI) and type III IFNs (IFNIII) signal through STAT1/STAT2 heterodimers, which recruit IFN regulatory factor 9 (IRF9) to generate the active IFNstimulated gene factor 3 (ISGF3) that binds IFNstimulated response elements (ISRE) in the nucleus (Qureshi et al , 1995