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Clinical evidence comes in tiers: mechanistic studies (does the molecule do what it should at the cellular level?), animal studies (does it produce the expected effect in a living organism?), and human trials (does it actually work on the people who will use it?)

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Reduced T3 levels in hypothyroidism impair Na+/K + ATPase regulation, affecting metabolic equivalents and causing symptoms such as fatigue, weight gain, cold intolerance, anxiety, constipation, hypothermia, decreased appetite and locomotion (Reference Kostoglou-Athanassiou and Ntalles1,Reference Fatourechi2)