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References Mahbub AA et al

Huang L, Lin L, Fu X, Meng C

KL: Formal analysis, Writing original draft, Project administration, Resources, Data curation, Visualization, Conceptualization, Investigation, Validation, Supervision, Methodology, Funding acquisition, Writing review & editing, Software

Native IGF-1 has 10-20 minute half-life, strong IGFBP binding limiting bioavailability, primarily local autocrine/paracrine actions, and rapid clearance