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In 2013 the FDA approved an injectable collagenase enzyme ( Xiaflex ) for treating Peyronies disease

(iii) If a generic Part D rebatable drug or biosimilar that is currently in shortage experiences a severe supply chain disruption, CMS will reduce the rebate amount as determined under paragraph (b)(1) of this section, and will not grant a reduction as set forth in 428.301 during that applicable period

In a study from 1995, for example, researchers at a Parke-Davis facility in Ann Arbor, Michigan, administered the substance to rats and found that it helped protect the rodents colons from harsh chemicals administered into their intestines an hour later

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