Application of butylamine as a conjugative reagent to on-column derivatization for the determination of antioxidant amino acids in brain tissue, plasma, and urine samples
More than 200 compounds, such as flavonoids, polysaccharides, triterpene saponins and certain trace elements, are found in Astragalus (14,15)

Correspondingly, combined treatment with sertraline, an inhibitor of serine/glycine conversion, and radiotherapy significantly impairs the proliferation, clonogenicity and stem cell self-renewal capacity of NSCLC cells, and also effectively suppresses tumor growth in in vivo experiments ( 4.1.2 Colorectal cancer Genes involved in the SSP are generally highly expressed in colorectal cancer and are correlated with unfavorable patient prognosis ( Meanwhile, activation of the Wnt pathway in turn promotes the transcription of SHMT2, forming a positive feedback loop of the SHMT2Wnt/-catenin axis that further strengthens the metabolic output of the SSP ( Clinical samples have confirmed that approximately 82% of OXPHOS-deficient colorectal cancer tissues harbor mtDNA mutations, and the SSP activity in these tumors is significantly higher than that in normal tissues ( The transcription factor FOXC1 has also been shown to reprogram serine metabolism under serine-deprived conditions to promote colorectal cancer proliferation and 5-fluorouracil resistance

10.1016/j.neubiorev.2005.03.009 41 DaileyM