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214 Under physiological conditions, increased Ca 2+ levels within mitochondria activate OXPHOS, stimulating ATP synthesis, inducing depolarization of the mitochondrial membrane, enhancing cellular respiration, activating Ca 2+ -dependent mitochondrial enzymes, and subsequently facilitating energy accumulation within mitochondria

Nature 577 249253

However, other types of cell death, such as typical necrosis and autophagy, also appear to be implicated in the death of melanocytes in patients with vitiligo

For example, RG108, a non-nucleoside inhibitor of DNMT, exerts an antitumour effect by reversing the silencing of antitumour genes such as GSTP1 and APC in prostate cancer (258)