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To examine key transition points in evolution of virulence and host adaptation in the dimorphic fungi, we increased the phylogenetic density within the Ajellomycetaceae by sequencing the genomes of non-pathogenic and emerging species and then performed comparative genomic analyses of the systemic, opportunistic, and non-pathogenic species

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Additionally, IN delivery bypasses the gastrointestinal tract and hepatic first-pass metabolism, potentially leading to improved bioavailability of oral iron chelators like DFP (Pires et al., 2009

doi: 10.1038/s41598-018-30823-w 111