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This relies on mitochondrial Ca 2+ accumulation, which is underpinned by the activation of pyruvate dehydrogenase kinase 4 (PDK4) and the subsequent stabilisation of key proteins involved in mitochondria-SR interactions, namely inositol 1,4,5-triphosphate receptor 1, 75-kDa glucose-regulated protein and voltage-dependant anion channel 1 (Thoudam et al., 2019)