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Research Enhanced Equity Fund - L Class JPMorgan Realty Income Fund - R6 JPMorgan Intrepid Value Fund I Class John Hancock Funds II Multimanager Lifestyle Aggressive Portfolio Class R1 John Hancock Funds II Multimanager Lifestyle Balanced Portfolio Class R1 John Hancock Funds II Multimanager Lifestyle Conservative Portfolio Class R1 John Hancock Funds II Multimanager Lifestyle Growth Portfolio Class R1 John Hancock Funds II Multimanager Lifestyle Moderate Portfolio Class R1 Janus Henderson Large Cap Value Fund - N Shares Janus Henderson Large Cap Value Fund - T Shares JPMorgan Research Market Neutral Fund Class L John Hancock Funds II Multi-Index 2060 Preservation Portfolio Class R4 Janus Henderson Global Value Fund - A Shares Janus Henderson Global Value Fund - C Shares JPMorgan Mid Cap Equity Fund - R6 Janus Henderson Global Value Fund - I Shares Janus Henderson Global Value Fund - N Shares Janus Henderson Global Value Fund - S Shares JPMorgan SmartRetirement Blend 2035 Fd R2 JPMorgan SmartRetirement Blend 2035 Fund I Class JPMorgan SmartRetirement Blend 2055 Fund I Class JPMorgan SmartRetirement Blend 2035 Fund - R4 JPMorgan SmartRetirement Blend 2035 Fund - R3 Janus Henderson Value Plus Income Fund - A Shares Janus Henderson Value Plus Income Fund - C Shares Janus Henderson Value Plus Income Fund - D Shares Janus Henderson Value Plus Income Fund - I Shares Janus Henderson Value Plus Income Fund N Shares JPMorgan International Value Fund-R5 Janus Henderson Value Plus Income Fund - S Shares Janus Henderson Value Plus Income Fund - T Shares JPMorgan International Value Fund R2 JPMorgan SmartRetirement Blend 2035 Fd R6 John Hancock Funds II Multimanager Lifestyle Aggressive Portfolio Class R2 John Hancock Funds II Multimanager Lifestyle Balanced Portfolio Class R2 John Hancock Funds II Multimanager Lifestyle Conservative Portfolio Class R2 John Hancock Funds II Multimanager Lifestyle Growth Portfolio Class R2 John Hancock Funds II Multimanager Lifestyle Moderate Portfolio Class R2 Janus Henderson Research Fund - A Shares Janus Henderson Research Fund - C Shares Janus Henderson Research Fund - I Shares Janus Henderson Research Fund - 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T Shares John Hancock Funds II Multi-Index 2060 Lifetime Portfolio Class 1 John Hancock Funds II Multimanager 2060 Lifetime Portfolio Class R4 John Hancock Alternative Risk Premia Fund Class R6 John Hancock Funds II Multi-Index 2040 Preservation Portfolio Class 1 John Hancock Funds II Multi-Index 2040 Preservation Portfolio Class R4 John Hancock Funds II Multi-Index 2040 Preservation Portfolio Class R1 John Hancock Funds II Multi-Index 2040 Preservation Portfolio Class R2 John Hancock Funds II Multi-Index 2040 Preservation Portfolio Class R6 Janus Henderson U.S

Quercetin suppressed CYP2E1-dependent ethanol hepatotoxicity via depleting heme pool and releasing CO

Hay DL, Chen S, Lutz TA, Parkes DG, Roth JD

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