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SIRT1 acts on the pathway of the peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1) (Tang, 2016), a fundamental regulator of energy metabolism (Thirupathi and de Souza, 2017) and mitochondrial dynamics (Singh et al., 2016) associated with an increase in antioxidant defenses through SOD2 and GSH (Liang and Ward, 2006

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Collectively, these studies suggest that SS-31 could be a cornerstone of future multimodal therapies

10.1038/s42003-024-06226-1 16 ChengR.WangX.HuangL.LuZ.WuA.GuoS.et al (2024)