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As cited above, a key manifestation of oxidative damage to oocytes in endometriosis is comprised by aberrations in the organization of oocyte meiotic spindles and chromosomes, a key morphologic marker for ROS damage and a widely regarded harbinger of impending oocyte and fetal aneuploidy ( Treatment horizons Given the in vitro studies showing that antioxidant supplementation of peritoneal and follicular fluids mitigates damage to human sperm, oocytes and embryos, it is logical to predict that in vivo treatments with antioxidants will improve parameters of fertility in endometriosis

Dihydroartemisinin inhibits the activation of the NF-B signaling pathway, reduces the expression of inflammatory factors (TNF- and IL-6), and decreases leukocyte counts for the treatment of radiation pneumonitis induced by A6MV-X-rays ( Excessive production of inflammatory factors can lead to lung damage ( 5.1.2 Antioxidant potential Extensive results carried out show that artesunate and dihydroartemisinin ameliorate oxidative stress in hyperoxia-induced and lipopolysaccharides (LPS)-induced lung injury in a dose-dependent manner, these compounds may increase nuclearrespiratoty factor 2 (Nrf2) levels in reactive oxygen species (ROS)-sensitive cells

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