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Using a 48-feature set, including 10 molecular features, 34 target-related features (e.g., target tissue selectivity), and 4 drug-like rules, ProCTOR constructs an RF classifier that directly predicts the likelihood of a drug being toxic in clinical trials [212]

The bases of the essential nature and toxicity of GSH The GSH requirement for viability could theoretically be linked to either its thiolredox or ironmetabolism functions, as both these processes are essential (Toledano et al , 2007