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For example, miR-106a, HIF-1/miR-210, miR-508-5p, and miRNA-19a/b are known to be involved in the development of chemoresistance (129, 132, 183, 184)

In cells that survive treatment, 5FU promotes a sustained increase in mitochondrial content over 72 h, as shown by changes in levels of nonyl-acridine orange (NAO) staining (Fig