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Altogether, these results suggest that inhibition of ferroptosis by targeting GSH metabolism is an important avenue for the development of new therapies for AD ( Oxidative Stress and Lipid Peroxidation Lipid peroxidation represents an important hallmark of AD (Sultana et al., 2013), which was also supported by the observed differential expression of ACSL3 and 4 in the course of the pathology (Tables 1, 2)

Terazawa S, Nakajima H, Shingo M, Niwano T, Imokawa G (2012) Astaxanthin attenuates the UVB-induced secretion of prostaglandin E2 and interleukin-8 in human keratinocytes by interrupting MSK1 phosphorylation in a ROS depletionindependent manner

10.1073/pnas.0602046103 Proc