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Introduction The success of GLP-1 drugs, most notably Ozempic and Mounjaro, has made peptides one of the most commercially attractive therapeutic areas in the world and, therefore, a key pillar in Big Pharmas strategy moving forward

In contrast, -amylase acts as an endonuclease, and the down-regulation of its activity reduces the random breakage of starch molecules and prevents the sudden accumulation of excess reducing sugars from impacting cellular osmotic homeostasis [84, 85]

The inflammasome can also be activated through a non-canonical pathway through sensing of internalized LPS, leading to the activation of caspase 4, also referred to as caspase 11, for the release of IL-1, IFN, and NF-B (106108)