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Mutations in SOD1 normally an antioxidant enzyme and TDP-43, a DNA/RNA-binding protein prove particularly instructive

He referred us to the protocol Defining informative priors for ensemble modeling in systems biology (Tsigkinopoulou et al., 2018), from which we followed the basic steps to produce log-normal distributions for each of the kcat and Km values

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Singh et al, 2021), Genes common among published target sets include those related to redox biology (i.e., GCLC , SLC7A11 , TXN ) and the pentose-phosphate pathway (PPP, i.e., PGD , TALDO1 ), in addition to many NADP-dependent metabolic enzymes (i.e., AKR1C1 , AKR1B10 , and CYP4F11 )