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Description

KCNJ10 gene mutations causing EAST syndrome (epilepsy, ataxia, sensorineural deafness, and tubulopathy) disrupt channel function

In this study, we noted that the strongest alterations in glutathione metabolism were in the liver, potentially because hepatic glutathione is produced at much higher concentrations (10 mM), whereas intracellular glutathione concentrations are approximately 12 mM [31]

Generation of optimized genetic vaccines by directed evolution

However, while these mechanistic insights are promising, the translation into robust clinical outcomes remains limited, and current evidence is largely derived from in vitro and animal models (123125)