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Although the evidence is limited, using locally administered antibiotics alone or in conjunction with nonsurgical or surgical interventions for peri-implantitis demonstrated positive results

10.1371/journal.pone.0242152 26

(2016) 11:e0161571

Pathway enrichment analysis suggested 23 key regulators of the CS response (Supplemental Table S5), including known factors like -catenin 36 , transforming growth factor 1 37 and KRAS 38 , while NUPR1, to the best of our knowledge, had not been described in the context of the airway epithelial response to CS (Fig