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Drug-withdrawal experiments have consistently demonstrated that these surviving cells regain their proliferative capacity upon removal of the therapeutic agent, confirming the reversible nature of this state and distinguishing DTP cells from clones with stable genetic resistance ( Table 1 summarizes the representative experimental strategies across studies

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Pathophysiological processes where melatonin plays important roles Antiapoptotic activity Almost all the studies that monitored the melatonin-dependent antiapoptotic activities include disease models characterized by the presence of a hypoxicischemia (HI) event