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Preclinical antitumor activity of a novel anti-c-KIT antibody-drug conjugate against mutant and wild-type c-KIT-positive solid tumors

In the parotid gland mitochondria, despite an undoubtedly significant improvement of these parameters compared to the HFD group (59% GSH, 19% GSSG, 186% GSH/GSSG ratio), we still observed considerably reduced GSH concentration (21%), increased GSSG (31%) and decreased GSH/GSSG ratio (50%) compared to the control group