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However, the solubility of oleolic acid in water is low and the lipid-water distribution coefficient is not favorable

Journal of Translational Medicine, 14(1), 1-11

In initial CKD stages skeletal resistance to the action of PTH may explain why low bone turnover predominates in a significant proportion of patients, together with other conditions that inhibit bone turnover such as reduced calcitriol levels, sex hormone deficiency, diabetes, Wnt inhibitors and uremic toxins