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In recent literature, Berry-Kravis et al

It is recommended to take it one hour before physical activity on an empty stomach, not before or after meals

To assess whether the transient buildup of BB in vitro with only 2 microbial strains represents the biochemical transformations that occur in the presence of gastrointestinal polymicrobial communities, the anaerobic metabolism of l-carnitine by fecal communities from 12 human healthy donors (all omnivores) was studied