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Interestingly, we observed that the cecal microbiome of previously-obese animals returned to the lean state through NNMTi treatment and LD switch was distinct from the cecal microbiome of continuously lean control animals

Cystinosin-LKG, the alternatively spliced isoform of cystinosin, has a broader localization that could be leveraged to reduce cystine accumulation, restore lysosomal function, and lower apoptosis rates in cystinotic proximal tubule cells [155]

Studies have shown that the iron-sequestering ferritin H chain (FTH) is synthesized in hepatocytes to limit iron-induced hepatic glucose-6-phosphatase (G6Pase) expression and oxidative inhibition

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