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The field of proteomics has benefitted from rapid increases in analytical and computational capabilities since the field was initiated in 1992 and, at the time, relied primarily on large 2D gels to separate the proteins

The spellings usually refer to the same AEDG tetrapeptide, but product identity still requires analytical confirmation

Method Literature search strategy Google Scholar and PubMed were searched on various dates between December 2016 and March 2017, ending on 15th March 2017 using the following terms, and variants thereof, and all articles discovered were considered for inclusion: (paracetamol OR acetaminophen hepatotoxicity) AND genetic differences/polymorphisms OR children/neonates/young people/paediatric OR older people/elderly/geriatric OR nutritional state/malnutrition OR body weight/low body weight OR alcohol/alcohol-dependence OR drug interactions/potentiation OR liver disease/chronic liver disease/liver failure

Keeling et al., 2008