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Yet, as with NRF2, tumor contexts complicate interpretation: HO-1 is overexpressed in some cancers, including HCC, where it actively supports tumor progression by enhancing survival via mechanisms such as increasing cancer cell proliferation, conferring resistance to chemo- and radiotherapy, and promoting angiogenesis, as indicated by its strong correlation with VEGF expression and microvascular invasion

& Parker, E.D

Using whole-cell patch-clamp electrophysiology and micro-fluorescence Ca 2+ measurement of rat brain slices, study has demonstrated that the inhibition of hyperpolarization-activated current (Ih) determines the synaptic excitability of DA neurons

10.1016/j.jep.2023.116888 J