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Upon cGAMP binding, STING moves to the ERGIC in a COPII- and ARF GTPase-dependent manner

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6 The screening model is valuable precisely because it is sensitive, but that sensitivity is also its limitation: many agents that look promising on dermal papilla cells never translate into clinically meaningful regrowth, because a follicle in a dish is insulated from the hormonal, vascular, immune, and mechanical realities of a living scalp