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Avian immunosuppressive viruses (including IBDV, MDV, and ALV) all evade PRR-mediated IFN-I signaling pathwaysincluding the IRF7/NF-B signaling axis and the IFNAR-JAKSTAT pathwayand suppress the hosts innate antiviral immunity through two-stage blocking, defined here as blockade of PRR-mediated IFN induction and blockade of IFNAR-JAKSTAT signaling, which is the core common mechanism of avian viral immune escape (129)

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