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A study in adults aged 70 and older showed increased heteroplasmy linked to an increased depression score.[ref] Rare mitochondrial mutations that cause mitochondrial diseases are also linked to major depressive disorder.[ref] In fact, one study of people with hereditary (genetic) mitochondrial diseases showed that 54% had major depressive disorder and 17% had bipolar disorder.[ref] Outside of the mitochondrial genome, genes in the nuclear genome that code for proteins in the mitochondria are also linked to depression

More recent clinical trials have found no difference in comparison to a placebo ( Several thiols have been tested for their ability to protect cells and animals against ionizing radiation, a source of oxidative stress

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Alcohol depletes glutathione: Chronic alcohol consumption severely reduces hepatic glutathione through increased oxidative stress during ethanol metabolism [6][35]