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A meta-analysis in 2022, examining previous studies, found that vitamin B12 can improve neuropathic symptoms and reduce pain in patients with diabetic neuropathy. If your vitamin B12 levels are too low, there are a few ways to increase your intake of the vital nutrient

A level of less than 150 pg per mL (111 pmol per L) is diagnostic for deficiency Methylmalonic Acid (MMA) test: MMA is a substance produced in the body during the breakdown of certain amino acids

Pharmacokinetic modeling and clinical experience support this approach, though no head-to-head randomized trial has compared 1.5 mg twice weekly versus 2.5 mg once weekly

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