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Capone et al., 2020

The predominant mechanism involves Tf/TfR1-mediated endocytosis, where transferrin-bound Fe 3+ binds to TfR1 on endothelial cells, is internalized into endosomes, acidified, and subsequently released into the cytosol via DMT1-mediated transport

Specifically, this policy is intended to enable us to assign new HCPCS codes for new brachytherapy sources to their own APCs, with prospective payment rates set based on our consideration of external data and other relevant information regarding the expected costs of the sources to hospitals