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This view has been further reinforced by studies 13 that combine NAC supplementation with common ovulation agents (such as Clomiphene and Letrozole)

Vitamin D: The "sunshine" vitamin

Additionally, hippocampal atrophy driven by excitotoxicity and persistent inflammation reduces glucocorticoid receptor expression, which have an inhibitory effect on the HPA axis, weakening negative feedback control

Other trials on potentially promising drug candidates for CIPN prevention, such as a fatty acid amide hydrolase inhibitor (BIA 10-2474, Table 1), were prematurely terminated due to serious adverse events noted in participants (death, severe neurological complications) [44]