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In addition, two trials assessing the long-term use of carglumic acid in patients with propionic or methylmalonic acidurias are currently underway (PROTECT and LOTUS) [34]

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[46] A pilot human study of cis-retinoic acid (cRA) with radiotherapy and interferon-a2a on locally advanced cervical cancer noted a 47-percent tumor response and 33-percent complete remission rate, with no grade 3 or 4 toxicity noted

However, this focus has shifted toward targeting cancer-related signaling pathways, such as GPCR, MAPK, PI3K/Akt/mTOR, Wnt--catenin, and Nrf2