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Figure 3 Besides the functions of Kir4.1, the glia water channel aquoporin-4 (AQP4) is involved in the control of ion and osmohomeostasis and its deletion results in an inflammatory response evidenced by the secretion of different proinflammatory cytokines such as interleukin 1 beta (IL1B), interleukin 6 (IL6), and inducible nitric oxide synthase (NOS2

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The adverse effects/risks and the pharmacokinetics/systemic exposure must be considered, especially if the drugs are combined [126]

Ultimately, the expression levels of key genes involved in M1 macrophage polarization (such as inducible nitric oxide synthase gene, IL-12, and IL-6) are downregulated, thereby inhibiting the polarization of macrophages to the proinflammatory M1 phenotype (71)