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The GSH/GSSG ratio usually indicates the level of cellular oxidative stress, which accelerates the conversion of GSH to GSSG and decreases the GSH/GSSG ratio [26]

the thiol is the thiol of a cysteine residue

The S4 transmembrane segment of the channels is rich in positively charged basic residues, and S4 is agreed to be important in voltage sensing, although the conceptual and structural basis for gating charge movement is the subject of intense controversy