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Judging from historical data, this figure ranks third in the past two decades

Additionally, SF demonstrated protective effects in rodent models of vascular cognitive impairment induced by ischemia at 56.4 mol/kg twice a week (112), subarachnoid hemorrhage at 282 mol/kg every 24 h (113), and intracerebral hemorrhage at 5.64 mol/kg twice a day (114), with upregulation of Nrf2 and reduced inflammation reported in the latter two

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Finally, don't overlook environmental toxins