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M., Perry, G

To address the ROS burst driven by ferroptosis and the imbalance of iron homeostasis, a study has developed a macrophage-targeting polysaccharide iron nanoenzyme, which possesses dual enzyme activities resembling catalase and peroxidase, capable of scavenging ROS, inhibiting lipid peroxidation, and controllably releasing Fe 2 to correct systemic iron deficiency [150]

Similarly, in ultrasound-triggered ROS generation systems such as lenvatinib nanoparticles (Len-RNPs), precise tumor targeting is essential to ensure that ROS are generated exclusively at the tumor site, thereby minimizing damage to surrounding healthy tissues

Infusion of adenosine directly into the knee in rats inhibited the development of adjuvant-induced arthritis, and an adenosine receptor antagonist effectively reduced the severity of joint inflammation in a collagen-induced arthritis model in mice [39, 40]