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Clinical manifestations: Herpes Labialis Accounts for 90% of HSV-1 infections Primary infection: fever, submandibular and cervical lymphadenopathy, multiple and nonclustered painful vesicles on lips, gingiva, palate, tongue (figures 2a and 2b) Recurrent eruption: pain and paresthesias followed by grouped vesicles on vermilion border Key diagnostic feature: recurrence in the same location ( figures 1 and 3 ) Herpetic Keratitis Eye pain, light sensitivity, discharge, gritty sensation Fluorescein stain confirms keratitis Other Nongenital HSV Infections Eczema herpeticum (Kaposi varicelliform eruption) is most commonly seen in children with uncontrolled underlying atopic dermatitis

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Kagan L, Gershkovich P, Wasan KM, Mager DE (2013) Dual physiologically based pharmacokinetic model of liposomal and nonliposomal amphotericin B disposition

Therefore, strategies aimed at reducing oxidative stress may offer metabolic benefits and disease prevention