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Cancer Cell 7 , 101111 (2005)

Specifically, mtDNA mutations lead to mitochondrial dysfunction, disrupting OXPHOS, reducing ATP production, and increasing ROS generation, which ultimately trigger apoptosis and genomic damage [97]

Control of cell cycle and immortality HDAC2 The role of histone deacetylase 2 (HDAC2) in GBM appears to regulate acetylation of histones 3 and 4 which were in turn found to potentiate brain tumor stem cell (BTSC) self-renewal