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237,238 AGEs accumulate in peripheral nerves and interact with the receptor for AGEs (RAGE) on cell surfaces, activating intracellular signaling pathways involving NF-B

Radmanesh, A

Beyond the pancreas: Contrasting cardiometabolic actions of GIP and GLP1

Additionally, the harmful effects of advanced glycation end products (AGEs), chronic neuroinflammation, and damage to the brain's blood vessels contribute to the progression of the disease (111)