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Some minor differences exist in the affinities of some compounds for the D 1 and D 5 receptors (higher agonist and lower antagonist affinities for D 5 ), but no compounds that decisively distinguish between those subtypes are currently available

Additionally, we hypothesized that at the cellular level, particularly in the transcriptome, the intervention would modify the expression of genes responsible for immune system responses, and that those changes could bring functional benefits that may not be reflected on the clinical measurements that we proposed as readouts

Eur J Neurosci 53:222235

Long-term oral phosphodiesterase 5 inhibitor therapy alleviates recurrent priapism